Flow cytometric analysis with annexin V/PI was performed 4 days after infection and revealed increased apoptosis and cell death in DDX21-shRNA-infected cells (26.9% annexin V+/PI-, 18.5% annexin V+/PI+ and 18.8% annexin V−/PI+) when compared to the controls (7.7/11.4% annexin V+/PI-, 11.4/11.9% annexin V+/PI+ and 4.2/2.6% annexin V−/PI+) (Figure 6D). This evidence concerns the gene ANXA5 and infection.