PRUNE2 is also related to heart tension with higher expression in the heart of the hypertensive blood pressure high (BPH) inbred strains of mice and lower expression in genetically hypotensive blood pressure low (BPL) inbred strains compared to the normotensive blood pressure normal (BPN) inbred strains (GDS3673; Figure 4E; P<0.05). Here, PRUNE2 is linked to blood pressure trait.