Furthermore, most studies investigating the impact of breadth of CD8+ T cell responses elicited during early HIV-1 infection in viral control have focused on samples from treated individuals during early HIV-1-infection [34], [67] and a panel of HLA-restricted epitopes [67], [68] or a limited selection of HIV-1 proteins [67] rather than using samples from therapy naïve individuals and peptide sets spanning the whole HIV-1 proteome. This evidence concerns the gene CD8A and HIV-1 infection.