Point mutation in AKT1 has been detected in Proteus syndrome [2], endometrial carcinomas [4], [7] and leukaemia [5], [8]–[9], gene amplification in a single gastric carcinoma out of a screen of more than 225 diverse human malignancies [10], and in 1 gliosarcoma out of 103 malignant glial cancers [11]. Here, AKT1 is linked to leukemia.