As shown in Figure 4A, HF patients with diabetes (10.45±5.76 ng/mL, n = 40) or without diabetes (8.42±5.87 ng/mL, n = 117) had higher plasma Sema4D levels than healthy controls (4.67±2.99 ng/mL, n = 126) (both P values <0.01). Here, SEMA4D is linked to diabetes mellitus.