Thus, targeting TAMS is a potential new approach for breast cancer treatment and the increase in CD68 and other immune related genes between the CNBs and EBs has several implications; first, window of opportunity clinical trials for immune modulating drugs and in general, changes in immune related genes after exposure to a drug may be difficult to interpret due to the inflammatory changes that are unrelated to drug exposure as shown in this study. This evidence concerns the gene CD68 and breast cancer.