Genetic variants in genes encoding two proteins with TG lipase activity, hepatic lipase (LIPC/HTGL) (Yamada et al, 2011) and lysophospholipase-like1 (LYPLAL1) (Speliotes et al, 2011), and the DGAT2 enzyme involved in TG synthesis (Kantartzis et al, 2009) have also been associated with the risk of developing hepatic steatosis. This evidence concerns the gene LIPC and fatty liver disease.