Atgl knockout mice are completely protected from adipose tissue wasting and had no increased lipolysis after inducing cachexia, despite high levels of lipid-mobilizing factors, such as zinc-alpha-2-glycoprotein 1 (AZGP1), tumour necrosis factor α (TNF-α), or interleukin-1 (Das et al, 2011). This evidence concerns the gene PNPLA2 and Cachexia.