Interestingly, it is highly likely that the cell of origin of acute promyelocytic leukaemia is downstream (a progenitor cell) of the cell of origin of ETV6–RUNX1-driven ALL and this may, in part, explain the less diverse mutational landscape reported in acute promyelocytic leukaemia compared with ALL and would fit well with our model. Here, ETV6 is linked to acute lymphoblastic leukemia.