The regression analysis was carried out to examine the relationship between metabolomic profiles and CRP without the confounding effect of variables that are known to influence metabolic status by assessing only individuals who were not current smokers (n = 67 in group 1 and n = 96 in group 2) and individuals without hypertension (n = 70 in group 1 and n = 96 in group 2), diabetes mellitus (n = 89 in group 1 and n = 118 in group 2), or hyperuricemia (defined as a uric acid level of >340 μmoles/liter; n = 58 in group 1 and n = 67 in group 2). The gene discussed is CRP; the disease is hyperuricemia.