NFATC2 and pulmonary arterial hypertension: Treatment of PAH PASMCs with VIVIT (a direct inhibitor of NFAT) or cyclosporine A (an indirect inhibitor of NFAT), lowered levels of nuclear activated NFATc2, reduced [K+]i and [Ca2+]i and depolarized PASMC mitochondria to levels comparable to normal PASMCs.