INS and metabolic dysfunction-associated steatohepatitis: Charlton et al. [68] showed that after feeding C57BL/6 mice for 6 months a fast food diet consisting of a high-fat chow (40% of energy from fat with 2% cholesterol) and drinking water enriched with high fructose corn syrup (HFCS, 42 g/L final concentration) mice not only became overweight and insulin resistant but also developed NASH and showed a gene expression signature of increased fibrosis.