Given the complexity of the p53 network, the several ways of p53 inactivation, and the recently described role of p53 in cancer invasiveness in mice, we studied in detail different levels of p53 inactivation in human colon cancer taking into account the allelic state of the locus on the short arm of chromosome 17, gene mutation state, protein expression levels, downstream target gene expression and determine the prognostic impact in colon cancer patients. Here, TP53 is linked to malignant colon neoplasm.