TGFB1 and glomerulosclerosis: It induces the fibrotic factor transforming growth factor-β (TGF-β) and fibronectin (FN), the renin-angiotensin-aldosterone system (RAAS), and advanced glycation end products both directly and via gene transcription, which leads to thickening of the glomerular and tubular basement membranes, progressive accumulation of extracellular matrix (ECM) proteins, interstitial fibrosis, and glomerulosclerosis [3–6].