POMC and gout: In addition, ACTH (which activates all melanocortin receptors, as discussed above) is currently used for the treatment of gout, but it displays efficacy also for proteinuric nephropathies [78], exacerbations of multiple sclerosis [79], and several rheumatic disorders [8, 9, 72, 80], indicating that targeting the melanocortin system might be a genuinely valid therapeutic approach.