The pro-apoptotic stimuli related to the pathophysiology of schizophrenia include (1) glutamatergic excitotoxicity, (2) excessive synaptic calcium flux, (3) oxidative stress, and (4) reduced neurotrophin levels (e.g., brain-derived neurotrophic factor BDNF, neurotrophin-3 NT-3) [9]. This evidence concerns the gene BDNF and schizophrenia.