BACE1 and Alzheimer disease: Another study conducted to examine the pattern of Aβ driven neurogenesis in a transgenic mouse model of AD-Tg-19959 showed that the use of LNA-modified siRNAs led to a marked decrease in the levels of insoluble Aβ peptides and altered the pattern of aggregation of soluble Aβ in the Tg-19959 mouse brain by targeting BACE1 and BACE-AS.