NFKB1 and neoplasm: The interaction between p53 and NF-κB reveals that, despite its role as a tumor suppressor, NF-κB becomes activated after reactivation of p53 even when the p53-induced apoptosis requires the participation of NF-κB. Thus, activation of NF-κB in apoptosis is additionally related to a hyperactivation of p53 [73].