The non-canonical pathway is activated by specific stimuli that include Lymphotoxin-β (LTβ) and B cell-activating factor (BAFF), whereas the canonical pathway is activated by a broader spectrum of stimuli, such as tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) and is often related to tumorigenesis, including leukemias, lymphomas, and some solid tumors [50–54]. The gene discussed is TNF; the disease is leukemia.