In fact, it has been described that nuclear PTEN interacts with the anaphase-promoting complex (APC/C) and induces its association with CDH1 (APC/C activator protein), thereby enhancing the suppressive capacity of the APC-CDH1 complex to advance cell division [91], thus indicating a role for nuclear PTEN in PCa suppression. Here, APC is linked to posterior cortical atrophy.