We have reported that epidermal PKCε levels dictate the susceptibility of PKCε transgenic (TG) mice to the development of squamous cell carcinomas (SCC) elicited either by repeated exposures to ultraviolet radiation (UVR) [8] or initiation with 7, 12-dimethylbenz[a]anthracene (DMBA) and tumor promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) [9]. Here, PRKCE is linked to squamous cell carcinoma.