Nrf2 knockout mice exposed to low-dose DEP for 8 weeks showed significantly increased airway hyperresponsiveness and counts of lymphocytes and eosinophils, together with increased concentrations of IL-12 and IL-13, and thymus and activation-regulated chemokine (TARC) in bronchoalveolar lavage (BAL) fluid compared with wild-type mice. The gene discussed is NFE2L2; the disease is airway hyperresponsiveness.