ApoE4 allele is also associated with an enhanced risk or severity of several other neurodegenerative disorders [6], with a faster progression of certain neuromuscular diseases, including diabetic neuropathy and human immunodeficiency viral neuropathy [7], and with neuroinflammation, in pathologies like multiple sclerosis [8], Parkinson's disease [9], [10] and those neurological diseases involving excitotoxic mechanisms [11]. The gene discussed is APOE; the disease is Parkinson disease.