AGT and cardiac hypertrophy: Here, we report that IMD attenuates the cardiac hypertrophy, fibrosis and myocyte apoptosis in a mouse model of myocardial hypertrophy induced by transverse aortic coarctation (TAC) and H9c2 cells stimulated by angiotensin II (Ang II) or isoprenaline (ISO) through inducing the protective autophagy, and further improving cardiac performance.