In particular, vascular endothelial growth factor-A (VEGF-A) and its receptors such as VEGF receptor-1(VEGFR-1) and VEGFR-2 have been implicated in induction of tumor-associated angiogenesis in HCC, while the VEGF-C/VEGFR-3 axis has been shown to be involved in lymphangiogenesis and subsequent lymph node metastasis (LNM) [7], [8], [9], [10], [11], [12]. This evidence concerns the gene FLT4 and hepatocellular carcinoma.