GST pulldown analyses have shown that Rab6 is not able to bind APP directly (data not shown), suggesting that Mint1 826, which is not only able to bind Rab6, but also APP, could indeed be an adaptor protein for this transport process and therefore might be an important player in the development of Alzheimer’s Disease. Here, APBA1 is linked to early-onset autosomal dominant Alzheimer disease.