‘Glioma Invasiveness Signaling’ (Genes: CD44, F2R, ITGAV, MMP9, RHOC, RND2, RND3, TIMP3, TIMP4) and ‘Glioblastoma Multiforme Signaling’ (Genes: CDK6, CDKN1A, EGFR, ITPR2, MYC, RHOC, RND2, RND3, TCF3, WNT5A)]. This evidence concerns the gene TIMP3 and central nervous system cancer.