Several pathways known to be important to glioma development were also at the top of the significant canonical pathways list, including ‘WNT/beta-Catenin Signaling’ (CD44, CDH2, DVL3, LRP1, MYC, SOX4, SOX9, SOX13, TCF3, TCF4, TLE3, WNT5A) and ‘mTOR Signaling’ (EIF3B, EIF3E, EIF3F, EIF4A1, HIF1A, PRKD1, RHOC, RND2, RND3). The gene discussed is DVL3; the disease is central nervous system cancer.