Confirming our gene list as involved with brain tumor development, ‘Glioma Invasiveness Signaling’ (CD44, F2R, ITGAV, MMP9, RHOC, RND2, RND3, TIMP3, TIMP4) and ‘Glioblastoma Multiforme Signaling’ (CDK6, CDKN1A, EGFR, ITPR2, MYC, RHOC, RND2, RND3, TCF3, WNT5A) were returned as significant pathways as well. The gene discussed is ITPR2; the disease is central nervous system cancer.