DSG3 and neoplasm: Figure 5A shows the average tumor volume over the 38 days of study between these groups. In the DSG3 silencing groups, tumor growth was sustained significantly slower compared to the controls. On average, SAS-sh2 decreased tumor growth by 50% at day 30 (P<0.001) and by 71% at day 38 (P<0.001). After mice being scarified, the tumor weight was measured as an average reduction of 63% in the DSG3 knockdown mice compared to control group (P<0.01).