In the cortex and hippocampus of male CHF mice, the analyzed proteins, such as APP, BACE1, APP C-Terminal fragments (CTFs), Bax, Bcl-2, total Tau (t-Tau) and phosphorylated Tau (p-Tau) did not exhibited any alterations when compared with the respective protein levels in brains of the SHAM group (Figure 6A, B). The gene discussed is APP; the disease is congestive heart failure.