PPFIA1 and breast cancer: Other regulating genes identified that could play a role in carcinogenesis include the RNA binding motif protein 6 (RBM6), which has been identified as part of a novel fusion gene in acute megakaryoblastic leukemia [29]; and protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1), which is amplified in up to 15% of breast cancer and frequently co-amplified with cyclin D1 (CCND1) [30].