The OPN level in the tumor tissues of the late intervention group (1.898±0.342) was also significantly lower than that of the negative control group (2.775±0.094; Table II: F=73.318, P<0.05) and the OPN level in the tumor tissues of the late intervention group (1.898±0.342) was significantly lower than that of the early intervention group (1.079±0.345; Table III: F=34.12, P<0.05). Here, SPP1 is linked to neoplasm.