PI-88, which is a complex mixture of highly sulphated oligosaccharides, has progressed to phase III clinical trials in postresection HCC, and this treatment represents the approach of developing heparin/HS-mimics to competitively interfere the formation of the HS/bFGF/FGFR complex [16–18]. The gene discussed is FGF2; the disease is hepatocellular carcinoma.