Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of nonalcoholic fatty liver disease is complex, animal models have shown that modulating important enzymes, such as ACC, FAS, and SCD-1, in fatty acid synthesis in liver may be a key for the treatment of nonalcoholic fatty liver disease [19]. The gene discussed is SCD; the disease is metabolic dysfunction-associated steatotic liver disease.