CASP3 and brain ischemia: This compound was tested for increasing [Ca2+] ion and activating protein kinase Cγ (PKCγ) following cerebral ischemia and reperfusion [37] and was also found to play a vital role in protecting PC12 cells from cobalt chloride-induced apoptosis by scavenging reactive oxygen species, inhibiting p38 phosphorylation, upregulating Bcl-XL expression, and decreasing caspase-3 activity [38].