Activation of the transcription factor STAT3 in both glioma cells and glioma TAMs has been suggested to be a key intracellular mediator coordinating the expression of these immunosuppressive molecules [48, 51], leading Brantley and Benveniste to describe STAT3 as a critical “molecular hub” linking multiple pathways in glioma biology [52]. This evidence concerns the gene STAT3 and central nervous system cancer.