Stimulation of c-Met by HGF/SF in human GBM cell lines has been shown to increase proliferation and invasive motility [74] and furthermore to induce angiogenesis in murine glioma tissues [76], yet it remains unclear if this latter effect is mediated through direct action on glioma endothelial cells or through induction of VEGF. This evidence concerns the gene HGF and glioma.