Moreover, a recent prospective study in patients with type 2 diabetes indicated that an increase in osteocalcin levels over a period of 6 months was associated not only with a decrease in glycosylated hemoglobin and an improved glucose tolerance but also with positive effects on triglycerides and HDL levels [41], suggesting that osteocalcin could exert a protective effect on cardiovascular risk, as further highlighted by other studies [50–52]. Here, BGLAP is linked to type 2 diabetes mellitus.