BGLAP and osteoporosis: Indeed, while initial clinical observations suggested that both total and undercarboxylated osteocalcin levels may be suppressed by antiresorptive treatment for osteoporosis [71, 72], a large retrospective analysis of postmenopausal women involved in randomized controlled trials with alendronate (a nitrogen containing bisphosphonate with potent antiresorptive activity on bone) failed to evidence any increase in diabetic risk in the treatment group as compared with place-treated subjects and even suggested a mild relative risk reduction with active treatment [73].