For example, inhibition of PPARγ suppressed pancreatic cancer cell motility in Capan-1 and Panc-1 cells [24], while its activation in AsPC-1 cells by the specific ligand rosiglitazone increased levels of the tumor suppressor PTEN and decreased levels of phosphorylated Akt [25] and induced caspase-mediated apoptosis in Miapaca-2 cells [26]. This evidence concerns the gene PPARG and familial pancreatic carcinoma.