GLIS3 is the single gene located within the confidence interval of the region of association with T1D [3], and the SNPs that have been reported to be associated with T1D, T2D and T2D-related traits are all in very strong linkage disequilibrium (LD) to each other (pairwise correlation coefficient r2 of 0.95 to 1.0 between the strongest associated SNPs for the key studies [3], [4], [6], [7], [44]), supporting the hypothesis that a unique variant near GLIS3 may be responsible for all the reported associations with these common diabetes and related traits. This evidence concerns the gene GLIS3 and type 1 diabetes mellitus.