To investigate the impact of InlAm-mNcad interaction on the infection process, we inoculated orally wt and E16P KI mice with Lm-inlAm or Lm. In Lm-infected E16P KI mice in which InlA-Ecad interaction is functional, InlA promoted Lm invasion of the small intestinal tissue and bacterial dissemination to spleen and liver as early as 2 days post infection (dpi) (Figure 6). This evidence concerns the gene CDH1 and infection.