PPARG and diabetes mellitus: The thiazolidinediones (pioglitazone, rosiglitazone, and troglitazone), also known as glitazones, are a class of drugs used in the treatment of type 2 diabetes mellitus, which acts by activating the group of nuclear receptors peroxisome proliferator-activated receptors (PPARs), with greatest specificity for PPARγ [50].