In a recent paper [57] it was shown that in CD patients use of steroids, as well as immune-suppressant and anti-TNF-α drugs, was associated with downregulation of MMP-9 and MMP-26 positive neutrophils and stromal TIMP-1 and TIMP-3 and this paralleled histology score and calprotectine. The gene discussed is TNF; the disease is Cowden disease.