PHF1 and Mental deterioration: Aβ activates Abl and induces p-Tau suggesting that Abl participates in Aβ-induced p-Tau, while Imatinib reduces AT8 and PHF1 levels of p-Tau (Cancino et al, 2011) and reverses cognitive decline (Cancino et al, 2008; Cancino et al, 2011) in AD mice.