PRKN and Alzheimer disease: These results were confirmed in human post-mortem brains (described in (Lonskaya et al, 2012a; Lonskaya et al, 2013)), which showed noticeable interaction in the cortex (Fig 1L), hippocampus (Fig 1N) and caudate (Fig 1P), but this was decreased (N = 7 control and 12 AD) in AD cortex (Fig 1M) and Hippocampus (Fig 1O), and caudate (Fig 1Q), reflecting alteration of parkin solubility in these brains.