Consistent with a global repression of viral gene expression immediately post infection, studies of histone proteins at low MOIs show that a substantial number of incoming viral genomes are associated with methylated histone proteins [56] and that this response could be mediated by the action of a number of cellular proteins (i.e., hDaxx, PML and Sp100) that accumulated at ND10 bodies. The gene discussed is PML; the disease is infection.