Most of the benefits, that is, increased early sensitivity for AMI and increased sensitivity for small myocardial infarctions of hs‐cTnT assays for routine AMI diagnosis can be achieved by the recommended application of the 99th‐percentile URL as a medical decision limit with the standard cTnT assay,1 however, at the price of reduced specificity for AMI, which was also seen with the use of hs‐cTnT in everyday practice. Here, TNNT2 is linked to myocardial infarction.