Although PFOA-related activation of human PPAR-γ has not been established (Takacs and Abbott 2007; Vanden Heuvel et al. 2006), activation of PPAR-γ through endogenous and exogenous ligands appears to have antiinflammatory effects in colitis models and is being explored for therapeutic potential (Dubuquoy et al. 2006). The gene discussed is PPARG; the disease is colitis.