Furthermore a study of Rosati et al. [12] showed that NOTCH1 and NOTCH2, together with their ligands Jagged1 –and 2 are constitutively activated in B-CLL cells but not in normal B cells, suggesting that NOTCH signaling is involved in survival and resistance to apoptosis in CLL. The gene discussed is JAG1; the disease is B-cell chronic lymphocytic leukemia.