Moreover, in the case of metastatic HER2+ breast cancer a tyrosine kinase inhibitor, lapatinib (Geyer et al., 2006), as well an antibody targeting HER2-HER3 dimerization, pertuzumab (Baselga et al., 2012), have also been approved by U.S. Food and Drug Administration (FDA) for treatment in combination with chemotherapy. Here, ERBB2 is linked to breast carcinoma.