Since the discovery of PML in APL, numerous studies have been conducted to link PML and PML NBs with various cellular functions including senescence, apoptosis, protein degradation, and antiviral defense (Everett and Chelbi-Alix, 2007; Bernardi et al., 2008; Krieghoff-Henning and Hofmann, 2008; Geoffroy and Chelbi-Alix, 2011; Rabellino and Scaglioni, 2013). This evidence concerns the gene PML and acute promyelocytic leukemia.