Promyelocytic leukemia has been implicated in resistance to EMCV since PML−/− MEFs are more sensitive to EMCV than wild-type cells (El Mchichi et al., 2010) and because specific PML isoforms, PMLIV, and its variant PMLIVa (missing exon 5), protect cells from EMCV infection (Table 3). The gene discussed is PML; the disease is acute promyelocytic leukemia.