It has been found that TLR4 ligand and H2O2 also have the potential to activate non-Smad pathways which could be activated by TGF-β1 [11]–[16], suggesting the possibility that TLR4 ligand and/or H2O2 might cooperate with TGF-β1 to induce sufficient activation of multiple signaling pathways, favoring metastatic potential of non-invasive tumor cells. This evidence concerns the gene TGFB1 and neoplasm.