Specifically, subjects with OSA had higher circulating concentrations of IL-2, IL-4, IL-5, IL-6, IL-8, IFN-gamma, and TNF-alpha and tended to have higher concentrations of TNF-beta, clearly indicating an activation of the Th-1 and Th-2 immune response. This evidence concerns the gene CXCL8 and obstructive sleep apnea syndrome.