In addition, in 750 SCCS patients who had received standard therapy with PEG-IFN-α and ribavirin, no significant associations were found between SNPs in CYP2R1, GC and DHCR7 and treatment outcome (SVR vs. no SVR; P = 0.9, 0.4, 0.2, respectively; Table 4), suggesting that the observed associations between these loci and HCC are specific for (HCV-induced) hepatocarcinogenesis. This evidence concerns the gene CYP2R1 and hepatocellular carcinoma.