CYP2R1 and hepatocellular carcinoma: Figure 1 shows the cumulative incidence of HCC in patients with the CYP2R1 risk genotype rs1993116 GG compared to those with the favorable genotypes GA and AA (P = 0.037, hazard ratio (HR) = 1.81 (95% confidence interval (CI) = 1.03–3.13).