The strong Genome Wide Association Study (GWAS) signal for TOMM40 rs2075650 is interpreted as an APOE hit, due to their strong LD, and often the biological implications are considered to originate from APOE. Interestingly, the rs2075650, rs11556505 (TOMM40) and rs429358 (APOE) haplotype show greater genome wide association with AD than TOMM40 rs20756505 alone (Potkin et al., 2009). This evidence concerns the gene APOE and Alzheimer disease.