HCRT and narcolepsy: In seminal review papers on this topic, it is currently stated that “... human narcoleptics, who have few or no orexin neurons, rarely exhibit stimulant abuse and seeking despite the fact that they are treated for years with stimulants ...” (Aston-Jones et al., 2009) or “... patients with narcolepsy are often treated using addictive amphetamine-like drugs such as methylphenidate, amphetamine and γ-hydroxybutyrate, but rarely become addicted to these drugs ...” (Tsujino and Sakurai, 2009).